Continuous Solid Dose Form

PCMM:  Continuous Processing Platform

Pfizer Inc has launched their Portable Continuous Miniature and Modular (PCMM) autonomous manufacturing unit for continuous oral solid dose form production. The equipment fits in a portable facility that can be shipped to any location, enabling medicines to be manufactured where and when they are needed.  
The advantages of PCMM are significant:

  - Reduced project timelines: the units can be positioned and installed within one week
  - Allows integration of a new vertical, in-line powder mixer for continuously blending pharmaceutical powder streams
  - Allows up to five process analytical technology (PAT) sensor systems within the continuous wet granulation and
    continuous direct compression process equipment
  - Integration of PerceptiveAPC, to read process and PAT signals into a real-time monitoring and control system
  - Lower upfront investment costs, lower operating costs (up to 35% energy and resource savings)
  - Efficient experimental studies, estimated ~10 times less material usage, ~10 times faster than batch equipment
  - Increased OEE and scale-up from R&D to full scale commercial production using the same equipment

Both PAT and Advanced Process Control are seamlessly embedded into the operator interface.  PAT is used to generate predictions of Critical Quality Attributes.  Model Predictive Control adjusts key process actuations in a co-ordinated manner, to minimise variability in final product quality, and respond to changes in raw material quality.

This provides a fully integrated environment for process monitoring, product quality assessment, and process control.

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